Little Brotheris a hilarious comedy for anyone who has never seen What About Bob?, Planes, Trains and Automobiles, The In-Laws, The Cable Guy, Due Date, or any other movie where a mild-mannered rule-follower has his life upended by an annoying, sometimes unhinged, foil. For the rest of us, this sweet-and-salty comedy will seem a bit familiar and has little going for it except as the most prominent movie role yet for the freewheeling, often crude, and very funny comedian Eric André. He plays Marcus, a psych ward escapee who tracks down Rudd, his long-ago mentee from the Big Brother program, played by John Cena. But André’s antics feel more silly than transgressive when paired with a film that’s otherwise so conventional, which is surprising considering that, at one point, Marcus has a catheter forcefully removed from his penis. That leaves Little Brother, as likable as it often is, destined to disappear into the maw of Netflix’s ever-expanding catalog of mid-grade original films.

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